Use of Macrolane VRF 30 in emicircumferential penis enlargement

Aesthet Surg J. 2013 Feb;33(2):258-64. doi: 10.1177/1090820X12472337.


Background: Penis enlargement is increasingly in demand. Methods for penis enlargement can be classified into surgical, nonsurgical (filling), and mechanical. Each method has shown only relatively successful results. A new formulation of injectable, stabilized, hyaluronic acid (HA)-based, nonanimal gel is available that may have applications for this use.

Objectives: The authors propose a new technique for emicircumferential-injection filling of the penis and assess the safety and efficacy of this procedure compared with lipofilling.

Methods: The authors retrospectively reviewed the charts of 83 patients who underwent penis enlargement with either their HA-injection technique or lipofilling between December 2007 and July 2011. Safety, efficacy, and patient satisfaction were assessed.

Results: The circumferential enlargement obtained from both techniques ranged from 3.2 to 4.5 cm, with a decrement during erection. In all patients, the increase in penis length ranged from 1.8 to 3.6 cm. No complications were seen in patients treated with HA, whereas 8 patients treated with lipofilling developed granuloma, and another experienced fat necrosis. The vast majority (n = 72) of patients reported being "very satisfied" with the results.

Conclusions: The ideal technique for penis enlargement should be nonsurgical, with a satisfactory and predictable result, a low rate of complications, and long-term stability. Emicircumferential enlargement with HA filler meets these requirements. However, results have been durable but not definitive, and repeated treatment (with associated costs) is necessary.

Publication types

  • Comparative Study

MeSH terms

  • Adipose Tissue / transplantation*
  • Adult
  • Cosmetic Techniques* / adverse effects
  • Fat Necrosis / epidemiology
  • Follow-Up Studies
  • Gels
  • Granuloma / epidemiology
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Male
  • Patient Satisfaction
  • Penis / surgery*
  • Retrospective Studies


  • Gels
  • Hyaluronic Acid