Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;47(4):308-13.
doi: 10.1097/MCG.0b013e31827874e3.

Biomarkers for Diagnosis and Monitoring of Celiac Disease


Biomarkers for Diagnosis and Monitoring of Celiac Disease

Marta Vives-Pi et al. J Clin Gastroenterol. .


Celiac disease (CD) is an autoimmune disorder, which damages the small intestine and is caused by ingestion of gluten in genetically susceptible individuals. The only known effective treatment is a lifelong gluten-free diet. Genetic risk factors have been identified and nearly all patients are HLA-DQ2 and/or HLA-DQ8 positive. Specific autoantibodies, IgA antitissue transglutaminase-2, antiendomysium, and antideaminated forms of gliadin peptide antibodies, are widely used as diagnostic aids in celiac patients. However, the discovery of new biomarkers may help in the diagnosis and follow-up of the disease. Recently, the molecule REG Iα, involved in tissue regeneration, has been proposed as a new biomarker of CD. REG Iα expression is increased in the target tissue and in the sera of celiac patients during damage and inflammation, decreasing after gluten-free diet. In this article we review the main biomarkers for diagnosis and monitoring of CD, focusing on the immune response-related mechanisms.

Similar articles

See all similar articles

Cited by 13 articles

  • Biosensors for Non-Invasive Detection of Celiac Disease Biomarkers in Body Fluids.
    Pasinszki T, Krebsz M. Pasinszki T, et al. Biosensors (Basel). 2018 Jun 16;8(2):55. doi: 10.3390/bios8020055. Biosensors (Basel). 2018. PMID: 29914179 Free PMC article. Review.
  • Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis.
    Eisfeld AJ, Halfmann PJ, Wendler JP, Kyle JE, Burnum-Johnson KE, Peralta Z, Maemura T, Walters KB, Watanabe T, Fukuyama S, Yamashita M, Jacobs JM, Kim YM, Casey CP, Stratton KG, Webb-Robertson BM, Gritsenko MA, Monroe ME, Weitz KK, Shukla AK, Tian M, Neumann G, Reed JL, van Bakel H, Metz TO, Smith RD, Waters KM, N'jai A, Sahr F, Kawaoka Y. Eisfeld AJ, et al. Cell Host Microbe. 2017 Dec 13;22(6):817-829.e8. doi: 10.1016/j.chom.2017.10.011. Epub 2017 Nov 16. Cell Host Microbe. 2017. PMID: 29154144 Free PMC article.
  • Expression of REG family genes in human inflammatory bowel diseases and its regulation.
    Tsuchida C, Sakuramoto-Tsuchida S, Taked M, Itaya-Hironaka A, Yamauchi A, Misu M, Shobatake R, Uchiyama T, Makino M, Pujol-Autonell I, Vives-Pi M, Ohbayashi C, Takasawa S. Tsuchida C, et al. Biochem Biophys Rep. 2017 Oct 23;12:198-205. doi: 10.1016/j.bbrep.2017.10.003. eCollection 2017 Dec. Biochem Biophys Rep. 2017. PMID: 29090282 Free PMC article.
  • Celiac disease in non-clinical populations of Japan.
    Fukunaga M, Ishimura N, Fukuyama C, Izumi D, Ishikawa N, Araki A, Oka A, Mishiro T, Ishihara S, Maruyama R, Adachi K, Kinoshita Y. Fukunaga M, et al. J Gastroenterol. 2018 Feb;53(2):208-214. doi: 10.1007/s00535-017-1339-9. Epub 2017 Apr 7. J Gastroenterol. 2018. PMID: 28389733
  • Biomarkers to Monitor Gluten-Free Diet Compliance in Celiac Patients.
    Moreno ML, Rodríguez-Herrera A, Sousa C, Comino I. Moreno ML, et al. Nutrients. 2017 Jan 6;9(1):46. doi: 10.3390/nu9010046. Nutrients. 2017. PMID: 28067823 Free PMC article. Review.
See all "Cited by" articles

Publication types

LinkOut - more resources