The frequency of 4 common gene polymorphisms in nonagenarians, centenarians, and average life span individuals

Angiology. 2014 Mar;65(3):210-5. doi: 10.1177/0003319712475075. Epub 2013 Feb 6.


Single nucleotide polymorphisms of angiotensin-converting enzyme (ACE) such as rs1799752, nuclear factor kappa B (NFkB) such as rs28362491 and cholesteryl ester transport protein (CETP) such as rs708272 (TaqB1) and rs5882 (I405V) were evaluated in nonagenarians, centenarians, and average life span individuals (controls). The study population (n = 307; 190 nonagenarians, 12 centenarians and 105 middle-aged controls) was genotyped for ACE, NFkB, and CETP genetic variants. The age of nonagenarian and centenarian group ranged between 90 and 111 years; centenarians and controls age ranged from 99 to 111, and from 18 to 80 years, respectively. The I carriers of ACE I/D gene were fewer in nonagenarians compared to centenarians (37.6% vs 62.5%, P = .016). The I carriers of ACE gene were more frequent in centenarians compared to controls (62% vs 41%, P = .045). No differences in frequency of common NFkB and CETP genotypes between patients with exceptional longevity and middle-aged patients were observed.

Keywords: angiotensin-converting enzyme; centenarians; cholesteryl ester transport protein; nonagenarians; nuclear factor kappa B; single nucleotide polymorphisms.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology
  • Alleles
  • Cholesterol Ester Transfer Proteins / genetics*
  • Gene Frequency*
  • Genotype
  • Humans
  • Middle Aged
  • NF-kappa B / genetics*
  • Peptidyl-Dipeptidase A / genetics*
  • Polymorphism, Single Nucleotide*


  • CETP protein, human
  • Cholesterol Ester Transfer Proteins
  • NF-kappa B
  • Peptidyl-Dipeptidase A