The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Pain. 1990 Jan;40(1):29-34. doi: 10.1016/0304-3959(90)91047-M.


In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diabetic Neuropathies / complications*
  • Double-Blind Method
  • H-Reflex / drug effects*
  • Humans
  • Injections, Intravenous
  • Lidocaine / administration & dosage
  • Lidocaine / therapeutic use*
  • Male
  • Nociceptors / drug effects*
  • Pain / drug therapy*
  • Pain / etiology
  • Pain / physiopathology
  • Reflex, Monosynaptic / drug effects*
  • Sensory Thresholds / drug effects


  • Lidocaine