Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;7:290.
doi: 10.3332/ecancer.2013.290. Epub 2013 Jan 31.

Antiemetic Activity of Volatile Oil From Mentha Spicata and Mentha × Piperita in Chemotherapy-Induced Nausea and Vomiting

Affiliations
Free PMC article

Antiemetic Activity of Volatile Oil From Mentha Spicata and Mentha × Piperita in Chemotherapy-Induced Nausea and Vomiting

Z Tayarani-Najaran et al. Ecancermedicalscience. .
Free PMC article

Abstract

Background: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV).

Methods: This was a randomised, double-blind clinical trial study. Prior to the study, patients were randomly assigned into four groups to receive M. spicata or M. × piperita. Statistical analysis included the χ(2) test, relative risk, and Student's t-test. Fifty courses were analysed for each group that met our eligibility criteria. The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. Patients or guardians recorded the number of emetic events, the intensity of nausea over 20 h of chemotherapy, as well as any possible adverse effects that occurred during this time.

Results: There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M. × piperita in both treatment groups (p < 0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

Conclusion: M. spicata or M. × piperita essential oils are safe and effective for antiemetic treatment in patients, as well as being cost effective.

Keywords: Lamiaceae; Mentha spicata; Mentha × piperita; chemotherapy-induced nausea and vomiting (CINV); essential oils.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

References

    1. Koeller J, Aapro M, Gralla R, et al. Antiemetic guidelines: creating a more practical treatment approach. Support Care Cancer. 2002;10:519–22. doi: 10.1007/s00520-001-0335-y. - DOI - PubMed
    1. Lindley C, Bernard S, Fields S. Incidence, duration of chemotherapy-induced nausea, vomiting in the out patient oncology population. J Clin Oncol. 1989;7:1142–9. - PubMed
    1. Molassiotis A, Saunders MP, Valle J, et al. A prospective observational study of chemotherapy-related nausea, vomiting in routine practice in a UK cancer centre. Support Care Cancer. 2008;16:2018. doi: 10.1007/s00520-007-0343-7. - DOI - PubMed
    1. Edris AE. Pharmaceutical, therapeutic potentials of essential oils, their individual volatile constituents: A review. Phytother Res. 2007;214:308–23. doi: 10.1002/ptr.2072. - DOI - PubMed
    1. Anderson LA, Gross JB. Aromatherapy with peppermint isopropyl alcohol or placebo is equally effective in relieving postoperative nausea. J Post Anesth Nurs. 2004;191:29–35. - PubMed

LinkOut - more resources

Feedback