Effect of blueberry feeding on lipids and oxidative stress in the serum, liver and aorta of guinea pigs fed on a high-cholesterol diet

Biosci Biotechnol Biochem. 2013;77(2):389-91. doi: 10.1271/bbb.120722. Epub 2013 Feb 7.

Abstract

We investigated the effect of blueberries (BB) on lipids and oxidative stress parameters in hypercholesterolemic guinea pigs. The animals were fed for 75 d on a high-cholesterol (HC) diet supplemented with fresh BB. BB reduced oxidative stress and cholesterol accumulation in the aorta and liver of the guinea pigs. This effect may be related to its antioxidative potential and lipid-reducing effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticholesteremic Agents / pharmacology
  • Aorta / drug effects
  • Aorta / metabolism*
  • Aorta / pathology
  • Blueberry Plants*
  • Cholesterol, Dietary / administration & dosage*
  • Diet, High-Fat
  • Flavonols / pharmacology
  • Guinea Pigs
  • Hypercholesterolemia / diet therapy*
  • Hypercholesterolemia / etiology
  • Hypercholesterolemia / metabolism
  • Hypercholesterolemia / pathology
  • Lipid Metabolism
  • Lipid Peroxidation
  • Liver / drug effects
  • Liver / metabolism*
  • Liver / pathology
  • Male
  • Oxidative Stress*
  • Polyphenols / pharmacology

Substances

  • Anticholesteremic Agents
  • Cholesterol, Dietary
  • Flavonols
  • Polyphenols