Thermal denaturation and renaturation of γ-glutamyltranspeptidase of Escherichia coli

Biosci Biotechnol Biochem. 2013;77(2):409-12. doi: 10.1271/bbb.120780. Epub 2013 Feb 7.

Abstract

Heat-treated γ-glutamyltranspeptidase of Escherichia coli recovered enzymatic activity after incubation at 4 °C, while heat-treated γ-glutamyltranspeptidase of Bacillus subtilis did not. Fluorescent spectra, CD spectra, and native polyacrylamide gel electrophoresis analysis suggested that the dimer of E. coli γ-glutamyltranspeptidase was separated into protomers by heat-treatment, but was renatured by incubation at 4 °C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus subtilis / enzymology*
  • Bacillus subtilis / genetics
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Protein Denaturation
  • Protein Multimerization
  • Protein Refolding
  • Protein Subunits / chemistry*
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Species Specificity
  • Temperature
  • gamma-Glutamyltransferase / chemistry*
  • gamma-Glutamyltransferase / genetics
  • gamma-Glutamyltransferase / metabolism

Substances

  • Bacterial Proteins
  • Protein Subunits
  • gamma-Glutamyltransferase