Neuropsychological detection of the early stage of amnestic mild cognitive impairment without objective memory impairment

Dement Geriatr Cogn Disord. 2013;35(1-2):98-105. doi: 10.1159/000346286. Epub 2013 Feb 6.


Aim: We investigate the assessment method to detect the early stage of amnestic mild cognitive impairment (aMCI) using Wechsler Memory Scale - Revised (WMS-R) and Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).

Methods: Three groups (normal group, aMCI group, and early aMCI group), controlled for age and years of education, underwent brain (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET), WAIS-III, WMS-R, and other tests. The early aMCI group does not fulfill the clinical diagnostic criteria of aMCI because patients do not have objective memory impairment, but their clinical symptoms and results of (18)F-FDG PET indicate that they should be included in the category of aMCI.

Results: The discrepancy of scores between Verbal IQ and General Memory had the highest accuracy in discriminating between normal and early aMCI groups.

Conclusion: The cutoff point determined in this study is useful to detect an early stage of aMCI, which may be distinguished from aMCI using the current criteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amnesia / diagnosis*
  • Amnesia / pathology
  • Amnesia / psychology
  • Analysis of Variance
  • Cognitive Dysfunction / diagnosis*
  • Cognitive Dysfunction / pathology
  • Cognitive Dysfunction / psychology
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Intelligence Tests
  • Japan
  • Logistic Models
  • Magnetic Resonance Imaging
  • Male
  • Memory / physiology*
  • Middle Aged
  • Neuropsychological Tests*
  • Positron-Emission Tomography
  • ROC Curve
  • Radiopharmaceuticals
  • Wechsler Scales


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18