Randomized controlled trial of the intraoperative bile leakage test in preventing bile leakage after hepatic resection

Dig Surg. 2012;29(6):510-5. doi: 10.1159/000346480. Epub 2013 Feb 6.


Aim: To evaluate the value of an intraoperative bile leakage test during liver resection in preventing bile leakage after hepatic resection.

Methods: A sterile fat emulsion was injected through the duct of the gallbladder among patients from the treatment group so as to observe leakage status on the hepatic resection plane; the leakage points were dealt with in time. The hepatic resection plane was treated using conventional methods among patients from the control group.

Results: The incidence rates of the bile leakage and other complications in the two groups were analyzed in this study. Two (3.7%) of the 53 patients from the treatment group had bile leakage, and 8 (14.8%) of the 54 patients from the control group had bile leakage. There were significant differences between the two groups (p < 0.05) in terms of the incidence of the bile leakage. With regard to the incidence of other complications, there were no significant differences between the two groups (p > 0.05).

Conclusions: An intraoperative bile leakage test appears to be sensitive in detecting interoperative bile leaks and can effectively prevent bile leakage after hepatic resection, and it does not increase the likelihood of other complications.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Bile*
  • Emulsions
  • Fats
  • Female
  • Hepatectomy*
  • Humans
  • Incidence
  • Intraoperative Care / methods*
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Suture Techniques
  • Treatment Outcome


  • Emulsions
  • Fats