Improving sperm quality and spermatogenesis through a bioactive marine compound: an experimental study

Acta Biomed. 2012 Aug;83(2):108-13.


Dietary lipids may affect sperm membrane structure, fluidity and its susceptibility to oxidative phenomena which may lead to altered sperm viability and proper binding to eggs. Given the recently demonstrated beneficial effects of fish oil diets on turkey fertility and embryo viability, the aim of this study was to test a caviar-derived marine product on spermatogenesis and sperm quality. Sixty mice were divided into four different groups and fed for 3 weeks with normal chow (group A), added with LD-1227 at the dosage of either 5 mg/day (B1) or 10 mg/day (B2) while Group C received standard chow added with 10 mg of a DHA-rich mixture. At sacrifice tests/body weight ration and spermatogenesis was checked. No toxicity, histological sign or body or testes growth abnormality was noted, irrespective of the treatment. As compared to control, all supplements showed to increase sperm counting and motility although the effect of LD-1227 10 mg was significantly higher than DHA alone (p<0.05). Viability was improved by DHA (p<0.05) but not by low LD-1227 dosage while higher dosage performed better than DHA (p<0.05). Morphology was unaffected by any of the employed supplements. Taken altogether, these data suggest that LD-1227 has a remarkable effect on quali-quantitative parameters of spermiogenesis, some of them being more effective than high dosage DHA. These findings may prove to be of interest in clinical practice. (

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dietary Supplements*
  • Docosahexaenoic Acids / administration & dosage*
  • Dose-Response Relationship, Drug
  • Fertility / drug effects*
  • Male
  • Mice
  • Sperm Count
  • Spermatogenesis / drug effects*
  • Spermatozoa / chemistry*
  • Spermatozoa / drug effects
  • Testis / cytology
  • Testis / drug effects


  • Docosahexaenoic Acids