Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)

Crit Care. 2013 Feb 4;17(1):204. doi: 10.1186/cc11454.


Acute kidney injury (AKI) is a common and serious problem affecting millions and causing death and disability for many. In 2012, Kidney Disease: Improving Global Outcomes completed the first ever, international, multidisciplinary, clinical practice guideline for AKI. The guideline is based on evidence review and appraisal, and covers AKI definition, risk assessment, evaluation, prevention, and treatment. In this review we summarize key aspects of the guideline including definition and staging of AKI, as well as evaluation and nondialytic management. Contrast-induced AKI and management of renal replacement therapy will be addressed in a separate review. Treatment recommendations are based on systematic reviews of relevant trials. Appraisal of the quality of the evidence and the strength of recommendations followed the Grading of Recommendations Assessment, Development and Evaluation approach. Limitations of the evidence are discussed and a detailed rationale for each recommendation is provided.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / therapy*
  • Blood Glucose / analysis
  • Coronary Artery Bypass, Off-Pump
  • Creatine / blood
  • Creatine / urine
  • Decision Support Techniques
  • Diuretics / therapeutic use
  • Fluid Therapy
  • Humans
  • Nutritional Support
  • Practice Guidelines as Topic*
  • Risk Assessment
  • Vasoconstrictor Agents / therapeutic use
  • Vasodilator Agents / therapeutic use


  • Blood Glucose
  • Diuretics
  • Vasoconstrictor Agents
  • Vasodilator Agents
  • Creatine