Strain-induced microstructural rearrangement in ultra-high molecular weight polyethylene for hip joints: A comparison between conventional and vitamin E-infused highly-crosslinked liners

J Mech Behav Biomed Mater. 2014 Mar:31:31-44. doi: 10.1016/j.jmbbm.2012.12.009. Epub 2013 Jan 11.

Abstract

Infusion of vitamin E (α-tocopherol) in highly crosslinked ultra-high molecular weight polyethylene (UHMWPE) liners has been conceived to achieve superior oxidation stability while preserving enhanced mechanical properties as compared to post-irradiation remelted liners. However, the presence of an antioxidant in the material microstructure brings an issue of concern in whether a "foreign substance" might reduce radiation crosslinking efficiency and/or change microstructural characteristics by diffusing into UHMWPE. The key to clarify this fundamental issue resides in performing a quantitative evaluation of the obtained material structure and its polymeric chain mobility on the molecular scale. In this paper, a Raman spectroscopic examination is presented of molecular orientation and phase fractions in as-processed vitamin E-infused UHMWPE acetabular liners in comparison with a model (undoped and unirradiated/uncrosslinked) and a conventional (undoped and 33kGy-sterilized by gamma-irradiation) UHMWPE liners. The microstructural responses of structurally different liners to externally applied compressive strain were also monitored. The main results of the spectroscopic analyses can be summarized as follows: (i) preliminary gamma irradiation reduced the fraction of amorphous phase and increased the degree of molecular alignment, the vitamin E-infused liner preserving the crystallinity level achieved by the 100-kGy irradiation injected before infusion; (ii) the presence of vitamin E significantly promoted orientational randomness, which increased with increasing compressive strain magnitude, a phenomenon beneficial to minimize strain-softening-assisted wear phenomena.

Keywords: Microstructure; Raman spectroscopy; Strain; UHMWPE; Vitamin E.

Publication types

  • Comparative Study

MeSH terms

  • Biocompatible Materials / chemistry*
  • Compressive Strength
  • Cross-Linking Reagents / chemistry*
  • Diffusion
  • Elastic Modulus
  • Equipment Failure Analysis
  • Hip Prosthesis*
  • Materials Testing
  • Molecular Conformation
  • Polyethylenes / chemistry*
  • Prosthesis Design
  • Stress, Mechanical
  • Tensile Strength
  • Vitamin E / chemistry*

Substances

  • Biocompatible Materials
  • Cross-Linking Reagents
  • Polyethylenes
  • ultra-high molecular weight polyethylene
  • Vitamin E