TCF7L2 and diabetes: a tale of two tissues, and of two species

Cell Metab. 2013 Feb 5;17(2):157-9. doi: 10.1016/j.cmet.2013.01.011.


Human genetics is revealing ever more variants that influence propensity to common diseases, but progress in translating these discoveries into the biological mechanisms responsible for predisposition continues to lag behind. A recent paper in Cell (Boj et al., 2012) using rodent models to examine how diabetes-associated variants near TCF7L2 perturb metabolic regulation provides surprising results.

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