In vitro human corticogenesis

Neuron. 2013 Feb 6;77(3):379-81. doi: 10.1016/j.neuron.2013.01.023.


Whether neurons generated in vitro from human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have in vivo-like properties is unknown. In this issue of Neuron, Espuny-Camacho et al. (2013) show that ESC-/iPSC-derived cortical neurons make specific projections and functional synapses when transplanted into a neonatal mouse brain.

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