SWItching on epidermal cell fate

Carolina N Perdigoto; Evan S Bardot; Elena Ezhkova

doi:10.1016/j.stem.2013.01.011

SWItching on epidermal cell fate

Cell Stem Cell. 2013 Feb 7;12(2):141-2. doi: 10.1016/j.stem.2013.01.011.

Authors

Carolina N Perdigoto¹, Evan S Bardot, Elena Ezhkova

Affiliation

¹ Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Chromatin regulatory complexes are well known regulators of stem cell fate; however, the mechanisms regulating their activity are not well understood. In this issue of Cell Stem Cell, Bao et al. (2013) show that ACTL6a inhibits targeting of the SWI/SNF complex to differentiation genes, thereby preserving the epidermal progenitor state.

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