The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis

Pancreatology. 2013 Jan-Feb;13(1):29-32. doi: 10.1016/j.pan.2012.12.059. Epub 2012 Dec 20.


Background/aims: The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients.

Methods: Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390).

Results: We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP.

Conclusion: This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcoholism / complications*
  • Alcoholism / genetics
  • Cohort Studies
  • Gene Frequency
  • Germany
  • Humans
  • Lipase / genetics*
  • Pancreatitis, Chronic / genetics*
  • Risk Factors


  • CEL protein, human
  • Lipase