Abstract
There are two homologous membrane-bound enzymes in Escherichia coli that catalyze reversible conversion between succinate/fumarate and quinone/quinol. Succinate:ubiquinone reductase (SQR) is a component of aerobic respiratory chains, whereas quinol:fumarate reductase (QFR) utilizes menaquinol to reduce fumarate in a final step of anaerobic respiration. Although, both protein complexes are capable of supporting bacterial growth on either minimal succinate or fumarate media, the enzymes are more proficient in their physiological directions. Here we evaluate factors that may underlie this catalytic bias. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.
Copyright © 2013 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Biocatalysis
-
Electron Transport
-
Electron Transport Complex II / chemistry
-
Electron Transport Complex II / metabolism*
-
Escherichia coli / enzymology
-
Escherichia coli / metabolism
-
Escherichia coli Proteins / chemistry
-
Escherichia coli Proteins / metabolism*
-
Fumarates / chemistry
-
Fumarates / metabolism
-
Models, Molecular
-
Molecular Structure
-
Oxidoreductases / chemistry
-
Oxidoreductases / metabolism*
-
Protein Binding
-
Protein Structure, Tertiary
-
Quinones / chemistry
-
Quinones / metabolism
-
Succinic Acid / chemistry
-
Succinic Acid / metabolism
Substances
-
Escherichia coli Proteins
-
Fumarates
-
Quinones
-
respiratory complex II
-
Succinic Acid
-
Oxidoreductases
-
Electron Transport Complex II
-
quinol fumarate reductase