Long-term dynamics of CA1 hippocampal place codes

Nat Neurosci. 2013 Mar;16(3):264-6. doi: 10.1038/nn.3329. Epub 2013 Feb 10.


Using Ca(2+) imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, as each day the ensemble representation of this environment involved a unique subset of cells. However, cells in the ∼15-25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • CA1 Region, Hippocampal / physiology*
  • Calcium / metabolism*
  • Environment
  • Memory / physiology
  • Mice
  • Pyramidal Cells / physiology*


  • Calcium