Assessment of adiponectin and its isoforms in Polish centenarians

Exp Gerontol. 2013 Apr;48(4):401-7. doi: 10.1016/j.exger.2013.01.015. Epub 2013 Feb 5.


Background: The physiological mechanisms that promote longevity remain unclear. It has been suggested that insulin sensitivity is preserved in centenarians, whereas typical aging is accompanied by increasing insulin resistance. The oldest-old individuals display raised total adiponectin levels, despite the potential correlation between enhanced adiponectin and all-cause and cardiovascular mortality.

Aim: To evaluate the level of adiponectin and its isoforms in sera of centenarians and to assess associations between adiponectin and metabolic parameters.

Participants: A group of 58 Polish centenarians (50 women and 8 men, mean age 101±1.34 years) and 68 elderly persons (55 women and 13 men, mean age 70±5.69 years) as controls.

Measurements: Serum samples were analyzed to evaluate the following parameters: adiponectin array (total adiponectin, HWM-, MMW- and LMW-adiponectin; all by ELISA methods), insulin (by IRMA methods), glucose and lipid profiles. HOMA-IR was calculated. Clinical data were collected. Statistical analyses were performed.

Results: The concentrations of all adiponectin isoforms were significantly higher in the oldest-old participants. In the centenarian group, total adiponectin positively correlated with age and HDL-cholesterol, and HMW-adiponectin was negatively associated with insulin and triglycerides. The long-lived participants had a lower incidence of hypertension, type 2 diabetes, overweight and obesity, with lower concentrations of serum glucose and insulin, and reduced HOMA-IR.

Conclusion: Our findings support the thesis that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in comparison with elderly individuals. However, additional work is necessary to understand the relevance of these findings to longevity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin* / blood
  • Adiponectin* / chemistry
  • Adiponectin* / metabolism
  • Adipose Tissue / metabolism
  • Aged
  • Aged, 80 and over
  • Blood Glucose / analysis
  • Body Mass Index
  • Cholesterol, HDL / blood
  • Diabetes Mellitus, Type 2* / blood
  • Diabetes Mellitus, Type 2* / metabolism
  • Female
  • Geriatric Assessment / methods
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Male
  • Molecular Weight
  • Obesity* / blood
  • Obesity* / metabolism
  • Protein Isoforms* / blood
  • Protein Isoforms* / chemistry
  • Protein Isoforms* / metabolism
  • Regression Analysis
  • Statistics as Topic
  • Triglycerides / blood


  • Adiponectin
  • Blood Glucose
  • Cholesterol, HDL
  • Insulin
  • Protein Isoforms
  • Triglycerides