[Prenatal risk calculation: comparison between Fast Screen pre I plus software and ViewPoint software. Evaluation of the risk calculation algorithms]

Ann Biol Clin (Paris). 2013 Jan-Feb;71(1):31-8. doi: 10.1684/abc.2012.0776.
[Article in French]


The Fetal medicine foundation (FMF) has developed a new algorithm called Prenatal Risk Calculation (PRC) to evaluate Down syndrome screening based on free hCGβ, PAPP-A and nuchal translucency. The peculiarity of this algorithm is to use the degree of extremeness (DoE) instead of the multiple of the median (MoM). The biologists measuring maternal seric markers on Kryptor™ machines (Thermo Fisher Scientific) use Fast Screen pre I plus software for the prenatal risk calculation. This software integrates the PRC algorithm. Our study evaluates the data of 2.092 patient files of which 19 show a fœtal abnormality. These files have been first evaluated with the ViewPoint software based on MoM. The link between DoE and MoM has been analyzed and the different calculated risks compared. The study shows that Fast Screen pre I plus software gives the same risk results as ViewPoint software, but yields significantly fewer false positive results.

Keywords: Fast Screen pre I plus software; Kryptor; degree of extremeness; prenatal risk calculation.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Algorithms*
  • Disease Susceptibility
  • Down Syndrome / diagnosis*
  • Female
  • Humans
  • Middle Aged
  • Models, Theoretical
  • Pregnancy
  • Prenatal Diagnosis / methods*
  • Risk Assessment
  • Software*
  • Young Adult