Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes

Arch Pharm Res. 2013 Feb;36(2):208-22. doi: 10.1007/s12272-013-0023-8. Epub 2013 Feb 10.


It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Adipose Tissue / pathology*
  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Inflammation / etiology
  • Inflammation / pathology
  • Inflammation / physiopathology
  • Insulin Resistance / physiology*
  • Macrophages / metabolism
  • Macrophages / pathology*
  • Obesity / metabolism
  • Obesity / pathology*