Psoriasis, a new challenge for laboratory medicine

Clin Chem Lab Med. 2013 Jul;51(7):1363-8. doi: 10.1515/cclm-2012-0653.

Abstract

Psoriasis is an immune-mediated, chronic, inflammatory disease that affects the skin and joints. Because of its high incidence and of its clinical symptoms it has a very strong social impact. In a genetically predisposed individual, the maintenance of the skin barrier integrity is strongly compromised in response to either environmental or self-antigenic insults. A persistent dysregulation of the skin immune system causes the typical evolutive skin lesions of psoriasis and recurrence of the disease. The most efficient laboratory approach consists of a well-defined evaluation of immune response in order to help diagnosis, to monitor evolution, and to evaluate the effects of individualized therapeutic treatments.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Biomarkers / analysis
  • Disease Progression
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / immunology
  • Gene Expression
  • HLA-C Antigens / genetics
  • HLA-C Antigens / immunology
  • Humans
  • Immune System / drug effects*
  • Interleukin-17 / antagonists & inhibitors
  • Interleukin-17 / genetics
  • Interleukin-17 / immunology
  • Interleukin-23 / antagonists & inhibitors
  • Interleukin-23 / genetics
  • Interleukin-23 / immunology
  • Polymerase Chain Reaction
  • Protein Array Analysis
  • Psoriasis / diagnosis*
  • Psoriasis / immunology
  • Psoriasis / pathology
  • Psoriasis / therapy*
  • Skin / drug effects
  • Skin / immunology*
  • Skin / pathology
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / pathology

Substances

  • Antibodies, Monoclonal
  • Biomarkers
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • HLA-C Antigens
  • HLA-C*06:02 antigen
  • Interleukin-17
  • Interleukin-23