RETRACTED: Tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis

Life Sci. 2013 Jul 19;93(1):7-16. doi: 10.1016/j.lfs.2013.02.001. Epub 2013 Feb 9.


This article has been retracted: please see Elsevier Policy on Article Withdrawal ( This article has been retracted at the request of the Editor-in-Chief. Multiple figures in this article appear to be falsified/fabricated. Figure 2A and C. The representative dot plots from the EGCG (15ug/ml)+CDDP (10ug/ml) and TF (15ug/ml) groups appear to be duplicated. Figures 3, 4 and 6. Multiple Western blot bands appear to be rotated and reused throughout Figure 3 (A and B); 4 (A and B) and 6 (A, B, C). In particular, the Cytochrome-c blot in Figure 3B is duplicated and flipped in Figure 6B as p-NFKB. The p53 blot in Figure 3B is duplicated in Figure 6C as p-NFKB. The B-actin blot in Figure 3B is shown as an unmarked control lane (flipped in Figure 6B. The p53 band in Figure 3C is very similar to the Caspase 9 blot in Figure 4B and is cropped and duplicated in Figure 6A as p-NFKB by cisplatin in SiHa cells. The Caspase 3 blot in Figure 4A is rotated and flipped and appears in Figure 6B as p-IKBa.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Analysis of Variance
  • Antineoplastic Agents / metabolism*
  • Antineoplastic Agents / therapeutic use
  • Apoptosis / drug effects*
  • Biflavonoids / pharmacology
  • Blotting, Western
  • Catechin / analogs & derivatives
  • Catechin / pharmacology
  • Cell Proliferation / drug effects
  • Cisplatin / metabolism*
  • Cisplatin / therapeutic use
  • Drug Resistance, Neoplasm / drug effects*
  • Female
  • HeLa Cells
  • Humans
  • Immunohistochemistry
  • Membrane Potential, Mitochondrial / drug effects
  • NF-kappa B / metabolism
  • Polyphenols / analysis
  • Polyphenols / pharmacology*
  • Proto-Oncogene Proteins c-akt / metabolism
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / drug effects
  • Tea / chemistry*
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / metabolism*


  • Antineoplastic Agents
  • Biflavonoids
  • NF-kappa B
  • Polyphenols
  • Reactive Oxygen Species
  • Tea
  • theaflavin
  • Catechin
  • epigallocatechin gallate
  • Proto-Oncogene Proteins c-akt
  • Cisplatin