Detection of ground-glass opacities by use of hybrid iterative reconstruction (iDose) and low-dose 256-section computed tomography: a phantom study

Radiol Phys Technol. 2013 Jul;6(2):299-304. doi: 10.1007/s12194-013-0200-y. Epub 2013 Feb 12.


The detection of ground-glass opacities (GGOs) is an important issue in lung cancer screening with low-dose CT. The iterative reconstruction (IR) technique has the ability to improve the image quality relative to the filtered back projection (FBP) technique with low-dose CT. Our purpose was to investigate the ability to detect GGO in a chest phantom using a low-dose CT and hybrid IR, named iDose. Simulated GGOs in a chest phantom were scanned with 256-section CT at tube current second products of 20, 50, 100, and 200 mAs. Five radiologists visually assessed the detectability of GGOs in the phantom. The contrast-to-noise ratio (CNR) for GGOs was used as an estimate of image quality. Comparison of the detectability and CNR between standard images with 200 mAs-FBP and low-dose images with 20, 50, and 100-mAs FBP/iDose were performed by ANOVA with Dunnett's and Tukey's test. The detectability was significantly lower at 20-mAs FBP/iDose and 50-mAs FBP than that at 200-mAs FBP (p < 0.05). There was no significant difference between 50-mAs iDose and 200-mAs FBP and between 100-mAs iDose/FBP and 200-mAs FBP. The CNR was significantly higher on iDose images than that on FBP images at each mAs value. The CNR at 200-mAs FBP was the same as that at 50-mAs iDose (CNR:1.8). The hybrid IR technique and low-dose CT imaging with 50 mAs enabled noise and to maintain the detectability for GGOs in a chest phantom that is equivalent to the reference acquisitions of 200 mAs with FBP.

MeSH terms

  • Algorithms*
  • Glass / chemistry*
  • Humans
  • Phantoms, Imaging*
  • Radiographic Image Interpretation, Computer-Assisted*
  • Radiography, Thoracic / instrumentation
  • Radiography, Thoracic / methods*
  • Solitary Pulmonary Nodule / diagnostic imaging*
  • Tomography, X-Ray Computed*