Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines

Int J Breast Cancer. 2013:2013:872743. doi: 10.1155/2013/872743. Epub 2013 Jan 16.


We reviewed the phenotypic and molecular characteristics of and the SUM cell lines based on numerous studies performed over the years. The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discovery and development use these cells to identify novel targets and biomarkers. Major signaling pathways and mutations affecting the coding sequence are also described providing important information when using these cells as a model in a variety of studies.