Complement-targeted therapeutics in periodontitis

Adv Exp Med Biol. 2013;735:197-206. doi: 10.1007/978-1-4614-4118-2_13.


Periodontitis is a prevalent oral chronic inflammatory disease which, in severe forms, may exert a major impact on systemic health. Clinical and histological observations, as well as experimental animal studies, suggest involvement of the complement system in periodontitis. However, the precise roles of the various complement components and pathways in periodontitis have only recently started to be elucidated. In this chapter, we review recent progress in the field and discuss the potential of complement-targeted therapeutics in the treatment of periodontitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Complement C5a / physiology
  • Complement System Proteins / physiology*
  • Humans
  • Periodontitis / drug therapy*
  • Periodontitis / microbiology
  • Periodontitis / physiopathology
  • Receptors, Complement / physiology


  • Receptors, Complement
  • Complement C5a
  • Complement System Proteins