Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jun;22(2):121-3.
doi: 10.1017/S204579601300005X. Epub 2013 Feb 12.

What Are Neuroimaging Meta-Analytic Procedures?

Free PMC article

What Are Neuroimaging Meta-Analytic Procedures?

S Cortese et al. Epidemiol Psychiatr Sci. .
Free PMC article


Activation likelihood estimation (ALE) meta-analyses allow investigators to integrate the results of multiple neuroimaging studies, potentially yielding novel results that may not have been evident in the individual studies. Here, we provide a brief, introductory description of ALE methods for readers without extensive expertise in neuroimaging.


Fig. 1.
Fig. 1.
(a) Tridimensional brain coordinates system. (b) Tridimensional Gaussian distribution. (c) Hypothetical example of an ALE meta-analysis of fMRI studies. Coloured areas might represent, for example, brain areas that are significantly more activated in individuals with a particular psychiatric disorder relative to comparisons across all studies retained in the meta-analysis. (A colour version of this figure is available online at

Similar articles

See all similar articles

Cited by 1 article