Anti-atherosclerotic mechanisms of statin therapy

Curr Opin Pharmacol. 2013 Apr;13(2):260-4. doi: 10.1016/j.coph.2013.01.004. Epub 2013 Feb 9.


HMG-CoA-Reductase inhibitors, also known as statins, are currently the most powerful cholesterol-lowering drugs available on the market. Clinical trials and experimental evidence suggest that statins have anti-atherosclerotic effects. These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. In this article, the anti-atherosclerotic actions of statins will be reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypercholesterolemia / drug therapy*
  • Hypercholesterolemia / metabolism
  • Hypercholesterolemia / physiopathology


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors