Sensitivity and specificity of detecting reticular pseudodrusen in multimodal imaging in Japanese patients

Retina. 2013 Mar;33(3):490-7. doi: 10.1097/IAE.0b013e318276e0ae.

Abstract

Purpose: To identify reticular pseudodrusen (RPD) in age-related macular degeneration using multiple imaging modalities, including the blue channel image of fundus photography, infrared reflectance (IR), fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and spectral-domain optical coherence tomography (SD-OCT), and to compare the sensitivities and specificities of these modalities for detecting RPD.

Methods: This study included 220 eyes from 114 patients with newly diagnosed age-related macular degeneration. Patients underwent fundus photography, IR, fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and SD-OCT in both eyes. Eyes were diagnosed with RPD if they showed reticular patterns on at least two of the seven imaging modalities.

Results: Thirty-seven eyes were diagnosed with RPD. However, SD-OCT and IR had the highest sensitivity (94.6%), and at the same time, SD-OCT had a high specificity (98.4%). The blue channel of color fundus photography, confocal blue reflectance, and indocyanine green angiography had a specificity of 100% but had lower sensitivity than that of SD-OCT and IR.

Conclusion: For detecting RPD, IR and SD-OCT had the highest sensitivity. Although SD-OCT had the highest sensitivity and specificity, RPD detection should be confirmed using more than one modality for increased accuracy.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asians / ethnology
  • Coloring Agents
  • Diagnostic Techniques, Ophthalmological*
  • False Positive Reactions
  • Female
  • Fluorescein Angiography
  • Humans
  • Indocyanine Green
  • Japan / epidemiology
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / ethnology
  • Male
  • Middle Aged
  • Ophthalmoscopy
  • Photography
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retinal Drusen / diagnosis*
  • Sensitivity and Specificity
  • Tomography, Optical Coherence
  • Visual Acuity / physiology

Substances

  • Coloring Agents
  • Indocyanine Green