Oxypurinol limits myocardial infarct size in closed chest dogs without pretreatment

Can J Cardiol. 1990 Apr;6(3):123-9.


The authors tested whether allopurinol or oxypurinol could limit infarct size when treatment was started just prior to reperfusion and continued until sacrifice. In closed chest, anesthetized dogs, a branch of the left coronary artery was reversibly occluded for 90 mins followed by 24 h of reperfusion. Fifteen minutes prior to reperfusion, dogs received a bolus of either allopurinol (10 dogs), or oxypurinol (nine dogs), 10 mg/kg intravenously, followed by a 24 h infusion, 55 mg/kg/day. Eleven control dogs received equal volumes of saline. Investigators were blinded to the identity of the agent. Hearts were removed 24 h after reperfusion. Arrhythmias for 30 mins after reperfusion were quantitated. Oxypurinol caused 28% less of the risk zone to infarct for any level of collateral flow than that seen in the controls. This difference was significant. Allopurinol-treated hearts averaged only 18% less infarction and did not achieve significance. Ventricular arrhythmias and mortality did not differ among the three groups. Therefore, unlike allopurinol, oxypurinol with continued administration can limit tetrazolium-indicated necrosis in the dog heart in the absence of pretreatment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Allopurinol / pharmacology
  • Animals
  • Collateral Circulation / drug effects
  • Coronary Circulation / drug effects*
  • Dogs
  • Electrocardiography / drug effects
  • Female
  • Male
  • Myocardial Infarction / pathology*
  • Myocardial Reperfusion Injury / pathology
  • Myocardium / pathology*
  • Oxypurinol / pharmacology*
  • Pyrimidines / pharmacology*
  • Risk Factors


  • Pyrimidines
  • Allopurinol
  • Oxypurinol