Abstract
IRONING OUT THE DIFFERENCES: A unified model shows that the catalytic centers of human H ferritin and archaeal P. furiosus ferritin load iron according to the same mechanism. This model could help our understanding of the processes of controlling the various subcellular concentrations of iron during inflammation.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Archaeal Proteins / chemistry
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Archaeal Proteins / metabolism*
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Catalytic Domain
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Ferritins / chemistry
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Ferritins / metabolism*
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Humans
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Inflammation / metabolism
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Iron / metabolism*
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Models, Biological
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Oxidative Stress*
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Pyrococcus furiosus / chemistry
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Pyrococcus furiosus / metabolism*
Substances
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Archaeal Proteins
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Ferritins
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Iron