A unified model for ferritin iron loading by the catalytic center: implications for controlling "free iron" during oxidative stress

Chembiochem. 2013 Mar 4;14(4):415-9. doi: 10.1002/cbic.201200783. Epub 2013 Feb 12.

Abstract

IRONING OUT THE DIFFERENCES: A unified model shows that the catalytic centers of human H ferritin and archaeal P. furiosus ferritin load iron according to the same mechanism. This model could help our understanding of the processes of controlling the various subcellular concentrations of iron during inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Archaeal Proteins / chemistry
  • Archaeal Proteins / metabolism*
  • Catalytic Domain
  • Ferritins / chemistry
  • Ferritins / metabolism*
  • Humans
  • Inflammation / metabolism
  • Iron / metabolism*
  • Models, Biological
  • Oxidative Stress*
  • Pyrococcus furiosus / chemistry
  • Pyrococcus furiosus / metabolism*

Substances

  • Archaeal Proteins
  • Ferritins
  • Iron