Research examining the perfectionism-burnout relationship has typically focused on the main effects of single dimensions of perfectionism. The purpose of the current study was to extend this research by examining the interactive effects of dimensions of perfectionism in predicting symptoms of athlete burnout. In doing so, the hypotheses of the recently developed 2 × 2 model of dispositional perfectionism were tested in regards to differences between subtypes of perfectionism. One hundred sixty-seven junior male soccer players were recruited from English professional soccer clubs and completed paper-and-pencil measures of perfectionism and symptoms of athlete burnout. Moderated hierarchical regression provided support for the hypotheses of the 2 × 2 model for some but not all symptoms of burnout. Overall, the findings suggest that the 2 × 2 model may offer a useful framework through which to explain the interactive effects of dimensions of perfectionism on athlete burnout.