Comparative analysis of lycopene in oxidative stress

J Assoc Physicians India. 2012 Jul;60:17-9.


Objective: Lycopene is a phytochemical, found in tomatoes having singlet oxygen quenching ability higher than other antioxidants, participates in most of chemical reactions to protect critical cellular biomolecules. Present study is to analyze effect of tomato's lycopene, synthetic lycopene, its placebo form in patients of OS.

Methods: Study includes 45 patients having oxidative stress, age 40-60 years and 30 age and sex matched healthy control. Blood samples were collected at the enrollment, end of 2 weeks of lycopene restricted diet and after 10 weeks of lycopene supplementation. Oxidative stress biomarkers MDA, SOD, GPX, GR, GSH, Catalase, vitamin C and E were measured.

Results: Results of study revealed decreased lipid peroxidation and OS after various forms of lycopene supplementation but comparative analysis showed significant increase in OS biomarkers except MDA in patients receiving synthetic lycopene as compare to natural and placebo form.

Conclusion: Dietary intake of tomato lycopene is beneficial to fight against OS but in the synthetic form it is more bioavailable and more effective against OS.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Antioxidants / pharmacology*
  • Ascorbic Acid / administration & dosage
  • Ascorbic Acid / blood
  • Biomarkers / blood*
  • Carotenoids / pharmacology*
  • Case-Control Studies
  • Dietary Supplements
  • Female
  • Humans
  • Lipid Peroxidation / drug effects*
  • Lycopene
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects*
  • Solanum lycopersicum / chemistry*


  • Antioxidants
  • Biomarkers
  • Carotenoids
  • Ascorbic Acid
  • Lycopene