Olive oil phenols and neuroprotection

Nutr Neurosci. 2013 Nov;16(6):243-9. doi: 10.1179/1476830513Y.0000000052. Epub 2013 Feb 11.


Olive oil is a rich source of phenolic components which have a wide variety of beneficial health effects in vitro, in vivo, and clinically. The beneficial effects of olive oil phenols attributed to a variety of biological activities including free radical scavenging/antioxidant actions, anti-inflammatory effects, anti-carcinogenic properties, and anti-microbial activities. On the other hand, olive oil phenols have been shown to be some of neuroprotective effects against cerebral ischemia, spinal cord injury, Huntington's disease, Alzheimer's diseases, multiple sclerosis, Parkinson's disease, aging, and peripheral neuropathy. This paper summarizes current knowledge on the mechanisms of neuroprotective effects of olive oil phenols.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / analysis
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / analysis
  • Antioxidants / therapeutic use
  • Apoptosis
  • Diet, Mediterranean
  • Fruit / chemistry*
  • Functional Food* / analysis
  • Humans
  • Neuroprotective Agents / analysis
  • Neuroprotective Agents / therapeutic use*
  • Olea / chemistry*
  • Olive Oil
  • Phenols / analysis
  • Phenols / therapeutic use*
  • Plant Oils / chemistry
  • Plant Oils / therapeutic use*


  • Anti-Inflammatory Agents
  • Antioxidants
  • Neuroprotective Agents
  • Olive Oil
  • Phenols
  • Plant Oils