Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens

Pediatr Exerc Sci. 2013 Feb;25(1):12-26. doi: 10.1123/pes.25.1.12.


We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40-55%VO2PeakR [(VO2Peak-VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined.

Results: Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat.

Conclusions: The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.

Trial registration: NCT00345436.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • African Americans
  • Body Composition
  • Body Weight
  • Chemokine CCL2 / blood
  • Exercise / physiology*
  • Exercise Test
  • Exercise Therapy*
  • Female
  • Glucose Tolerance Test
  • Hispanic Americans
  • Humans
  • Insulin Resistance / physiology*
  • Leptin / blood
  • Male
  • Obesity, Morbid / ethnology
  • Obesity, Morbid / physiopathology*
  • Obesity, Morbid / therapy*
  • Oxygen Consumption
  • Peroxidase / blood
  • Pilot Projects
  • Receptors, Tumor Necrosis Factor / blood
  • Resistin / blood
  • Statistics, Nonparametric


  • Chemokine CCL2
  • Leptin
  • Receptors, Tumor Necrosis Factor
  • Resistin
  • Peroxidase

Associated data