Predictive monitoring for early detection of sepsis in neonatal ICU patients

Curr Opin Pediatr. 2013 Apr;25(2):172-9. doi: 10.1097/MOP.0b013e32835e8fe6.


Purpose of review: Predictive monitoring is an exciting new field involving analysis of physiologic data to detect abnormal patterns associated with critical illness. The first example of predictive monitoring being taken from inception (proof of concept) to reality (demonstration of improved outcomes) is the use of heart rate characteristics (HRC) monitoring to detect sepsis in infants in the neonatal ICU. The commercially available 'HeRO' monitor analyzes electrocardiogram data from existing bedside monitors for decreased HR variability and transient decelerations associated with sepsis, and converts these changes into a score (the HRC index or HeRO score). This score is the fold increase in probability that a patient will have a clinical deterioration from sepsis within 24 h. This review focuses on HRC monitoring and discusses future directions in predictive monitoring of ICU patients.

Recent findings: In a randomized trial of 3003 very low birthweight infants, display of the HeRO score reduced mortality more than 20%. Ongoing research aims to combine respiratory and HR analysis to optimize care of ICU patients.

Summary: Predictive monitoring has recently been shown to save lives. Harnessing and analyzing the vast amounts of physiologic data constantly displayed in ICU patients will lead to improved algorithms for early detection, prognosis, and therapy of critical illnesses.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Early Diagnosis
  • Electrocardiography / methods
  • Heart Rate / physiology
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intensive Care Units, Neonatal
  • Intensive Care, Neonatal / methods*
  • Monitoring, Physiologic / methods
  • Sepsis / diagnosis*