Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes

Chromosoma. 1990 Apr;99(1):3-10. doi: 10.1007/BF01737283.


The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphibians / genetics
  • Animals
  • Base Sequence
  • Biological Evolution
  • Birds / genetics
  • Chromosome Banding
  • Chromosomes*
  • DNA*
  • Fishes / genetics
  • Karyotyping
  • Mammals / genetics
  • Nucleic Acid Hybridization
  • Repetitive Sequences, Nucleic Acid*
  • Reptiles / genetics
  • Species Specificity
  • Vertebrates / genetics*


  • DNA