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Review
. 2013;20(13):1639-45.
doi: 10.2174/0929867311320130004.

Polypharmacology in a Single Drug: Multitarget Drugs

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Review

Polypharmacology in a Single Drug: Multitarget Drugs

M L Bolognesi. Curr Med Chem. .

Abstract

Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most suited to treating currently incurable diseases. It is driven by a worldwide demand for safer, more effective, and affordable medicines against the most complex diseases, and by the failures of modern drug discovery to provide these. Polypharmacology can involve combinations and/or multitarget drugs (MTD). Although not mutually exclusive, my premise is that MTDs have inherent advantages over combinations. This review article focuses on MTDs from a medicinal chemistry perspective. I will explore their use in current clinical practice, their likely application in the future, and the challenges to be overcome to achieve this goal.

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