Taurine and epilepsy

Epilepsy Res. 2013 May;104(3):187-94. doi: 10.1016/j.eplepsyres.2013.01.010. Epub 2013 Feb 12.

Abstract

Dysfunction of excitatory and inhibitory neurotransmitters or neuromodulators is thought to underlie epileptic symptoms. Taurine, 2-aminoethanesulfonate, is a ubiquitous free amino acid abounding in the brain of humans and most animal species. It hyperpolarizes neurons and inhibits their firing. It may be a participating factor in certain subpopulations of epilepsy patients but its deficiency is not a universal prerequisite for seizures. Here, the participation of taurine in animal seizure models and human epilepsy patients is reviewed.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • Disease Models, Animal
  • Epilepsy / metabolism*
  • Epilepsy / physiopathology
  • Humans
  • Neurotransmitter Agents / metabolism
  • Taurine / deficiency
  • Taurine / metabolism*

Substances

  • Amino Acids
  • Neurotransmitter Agents
  • Taurine