A practical approach to high-resolution CT of diffuse lung disease

Eur J Radiol. 2014 Jan;83(1):6-19. doi: 10.1016/j.ejrad.2012.12.028. Epub 2013 Feb 11.


Diffuse lung disease presents a variety of high-resolution CT findings reflecting its complex pathology, and provides diagnostic challenge to radiologists. Frequent modification of detailed pathological classification makes it difficult to keep up with the latest understanding. In this review, we describe a practical approach to high-resolution CT diagnosis of diffuse lung disease, emphasizing (1) analysis of "distribution" of the abnormalities, (2) interpretation of "pattern" in relation to distribution, (3) utilization of associated imaging findings and clinical information, and (4) chronicity of the findings. This practical approach will help radiologists establish a way to interpret high-resolution CT, leading to pin-point diagnosis or narrower differential diagnoses of diffuse lung diseases.

Keywords: CT; Diffuse lung disease; High-resolution CT; Interstitial lung disease; Lung.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Radiographic Image Enhancement / methods*
  • Radiography, Thoracic / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*