Breaking news on fragile sites in cancer

Cancer Cell. 2013 Feb 11;23(2):137-9. doi: 10.1016/j.ccr.2013.01.017.


Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and creates a compelling link between replication stress, transcription, and chromosome rearrangements.

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