Association of the candidate gene SLC1A1 and obsessive-compulsive disorder in Han Chinese population

Psychiatry Res. 2013 Oct 30;209(3):737-9. doi: 10.1016/j.psychres.2012.12.016. Epub 2013 Feb 12.

Abstract

This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese. The G-A-C-G and G-G-T-C haplotypes were found to be significantly associated with OCD in overall samples, male samples and female samples.

Keywords: Glutamate transporter gene; Haplotype; Obsessive–compulsive disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / ethnology
  • Asian Continental Ancestry Group / genetics
  • Case-Control Studies
  • Excitatory Amino Acid Transporter 3 / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Male
  • Obsessive-Compulsive Disorder / epidemiology
  • Obsessive-Compulsive Disorder / ethnology
  • Obsessive-Compulsive Disorder / genetics*
  • Polymorphism, Single Nucleotide / genetics*

Substances

  • Excitatory Amino Acid Transporter 3
  • SLC1A1 protein, human