Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

S A Toorongian; G K Mulholland; D M Jewett; M A Bachelor; M R Kilbourn

doi:10.1016/0883-2897(90)90052-3

Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

Int J Rad Appl Instrum B. 1990;17(3):273-9. doi: 10.1016/0883-2897(90)90052-3.

Authors

S A Toorongian¹, G K Mulholland, D M Jewett, M A Bachelor, M R Kilbourn

Affiliation

¹ Department of Internal Medicine, University of Michigan, Ann Arbor 48109.

PMID: 2341282
DOI: 10.1016/0883-2897(90)90052-3

Abstract

Resin-supported [18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [18F]FDG. "No-carrier-added" [18F]fluoride ion is collected on a quaternary 4-(N,N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mann opyrannose. Acidic hydrolysis yields [18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anion Exchange Resins
Deoxy Sugars*
Deoxyglucose* / analogs & derivatives
Fluorine Radioisotopes*
Fluorodeoxyglucose F18
Isotope Labeling / methods*

Substances

Anion Exchange Resins
Deoxy Sugars
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Deoxyglucose

Grants and funding

NS 15655/NS/NINDS NIH HHS/United States