Healing properties of surface-coated polycaprolactone-co-lactide scaffolds: a pilot study in sheep

J Biomater Appl. 2014 Jan;28(5):654-66. doi: 10.1177/0885328212471409. Epub 2013 Feb 13.


The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds were implanted into a 3 cm sheep tibia critical size defect for 3 or 12 months (n = 5 each). Bone healing was estimated by quantification of bone volume in the defects on computer tomography and microcomputer tomography scans, plain radiographs, biomechanical testing as well as by histological evaluations. New bone formation occurred at the proximal and distal ends of the tibia in both groups. The current pilot study revealed a mean new bone formation of 63% and 172% after 3 and 12 months, respectively. The bioactive, surface coated, highly porous three-dimensional polycaprolactone-co-lactide scaffold stack itself acted as a guide rail for new bone formation along and into the implant. These preliminary data are encouraging for future experiments with a larger group of animals.

Keywords: Polycaprolactone-co-lactide scaffold; bone healing; collagen type I and chondroitin sulfate; sheep; tibia defect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coated Materials, Biocompatible*
  • Polyesters*
  • Sheep
  • Surface Properties
  • Tissue Scaffolds*
  • Wound Healing*
  • X-Ray Microtomography


  • Coated Materials, Biocompatible
  • Polyesters
  • polycaprolactone-co-lactide