A mouse following in the footsteps of human prehistory

Samuel H Vohr; Richard E Green

doi:10.1016/j.cell.2013.01.039

A mouse following in the footsteps of human prehistory

Cell. 2013 Feb 14;152(4):667-8. doi: 10.1016/j.cell.2013.01.039.

Authors

Samuel H Vohr¹, Richard E Green

Affiliation

¹ Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.

PMID: 23415216
DOI: 10.1016/j.cell.2013.01.039

Abstract

One of the strongest signals of positive selection in humans surrounds the V370A variant of Ectodysplasin A receptor (EDAR). However, its phenotypic consequences and impetus for selection are not well understood. Kamberov et al. nail down when it originated and, using transgenic mice, delineate its phenotypic impacts.

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