Stability studies of ascorbic acid 2-glucoside in cosmetic lotion using surface response methodology

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1583-7. doi: 10.1016/j.bmcl.2013.01.111. Epub 2013 Jan 30.


Ascorbic acid 2-glucoside (AA-2G) has been widely used in cream and lotion types of cosmetic products. Thus, the degradation of AA-2G caused by the temperature change and pH variation was very critical for determining the bio-functionality of cosmetics. Response surface methodology (RSM) was introduced to study the influence of temperature and pH on the stability of AA-2G. The optimal condition of retaining AA-2G with the highest stability was determined to be 55.3°C and pH 6.4. The antioxidative activities of AA-2G including DPPH and ABTS free radical scavenging activities, metal chelating activity, and reducing ability were also determined. AA-2G was a good ascorbic acid derivative which could be used in cosmetic products as an active ingredient.

MeSH terms

  • Ascorbic Acid / analogs & derivatives*
  • Ascorbic Acid / chemistry
  • Chelating Agents / chemistry
  • Cosmetics / chemistry*
  • Drug Stability
  • Free Radical Scavengers / chemistry
  • Hydrogen-Ion Concentration
  • Metals / chemistry
  • Oxidation-Reduction
  • Temperature


  • Chelating Agents
  • Cosmetics
  • Free Radical Scavengers
  • Metals
  • ascorbic acid 2-O-glucoside
  • Ascorbic Acid