Protein-protein interactions: A PUMA mechanism unfolds

Nat Chem Biol. 2013 Mar;9(3):141-3. doi: 10.1038/nchembio.1177.

Abstract

PUMA is a BCL-2 family protein that transmits stress signals to promote apoptosis. Upon DNA damage, a unique binding determinant within PUMA triggers partial unfolding of BCL-XL, resulting in the release of sequestered p53 and commitment to p53-dependent cell death.

Publication types

  • News
  • Comment

MeSH terms

  • Apoptosis Regulatory Proteins / metabolism*
  • Apoptosis*
  • Humans
  • Protein Unfolding*
  • Proto-Oncogene Proteins / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*
  • bcl-X Protein / metabolism*

Substances

  • Apoptosis Regulatory Proteins
  • BBC3 protein, human
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • bcl-X Protein