Physicochemical studies and biological evaluation on (E)-3-(2-(1-(2-hydroxyphenyl)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide complexes

Abstract

Hydrazone complexes of Co(II), Ni(II), Cu(II), Pd(II), Cd(II), Zn(II) and U(VI)O2 with (E)-3-(2-(1-(2-hydroxyphenyl)hydrazinyl)-3-oxo-N-(thiazol-2yl)propanamide (H2o-HAH) have been synthesized. The complex structure has been elucidated by analysis (elemental and thermal), spectroscopy ((1)H NMR, (13)C NMR, IR, UV-visible, ESR, MS) and physical measurements (magnetic susceptibility and molar conductance). The kinetic and thermodynamic parameters for the different decomposition steps of some complexes have been calculated using the Coats-Redfern equation. Also, the association and formation constants of Co(II) ion in absolute ethanol solutions at 294.15K have been calculated by using electrical conductance. Moreover, the ligand and its complexes have been screened for their antibacterial (Escherichia coli and Clostridium sp.) and antifungal activities (Aspergillus sp. and Stemphylium sp.) by MIC method.