Naturally derived factors and their role in the promotion of angiogenesis for the healing of chronic wounds

Angiogenesis. 2013 Jul;16(3):493-502. doi: 10.1007/s10456-013-9341-1. Epub 2013 Feb 17.


Chronic diseases such as vascular disease and diabetes are witnessing a global increase in prevalence. Such diseases often predispose patients to the development of severe, debilitating, chronic wounds. Angiogenesis, the formation of new capillaries from the pre-existing vascular network, is an essential component of wound healing and aberrant angiogenesis is evident in almost all chronic wounds. Natural products, derived from both plants and animals, provide a significant haven of compounds which have proved to be of great benefit to man and his ailments. Whilst significant advances have been made in the understanding of impaired angiogenesis in a non-healing wound, in the clinical setting, few effective agents exist that can expedite wound healing and closure. The lack of effective healing agents has led to a renewed interest in investigations into natural wound healing resources. In this review, we collate new evidence that details the potential for several natural compounds to promote angiogenesis and wound healing, most predominately via the up regulation of VEGF expression, that warrant urgent further investigation for development into new pro-angiogenic/wound healing therapies.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inducing Agents / pharmacology*
  • Animals
  • Biological Products / pharmacology*
  • Chronic Disease / drug therapy*
  • Humans
  • Insecta
  • Intercellular Signaling Peptides and Proteins / pharmacology*
  • Larva / metabolism
  • Larva / physiology
  • Models, Biological
  • Neovascularization, Physiologic / drug effects*
  • Neovascularization, Physiologic / physiology
  • Phenols / pharmacology
  • Plant Extracts / pharmacology
  • Wound Healing / physiology*


  • Angiogenesis Inducing Agents
  • Biological Products
  • Intercellular Signaling Peptides and Proteins
  • Phenols
  • Plant Extracts