Filipina nurses represent the majority of all internationally educated nurses recruited to work in the US. Although the hiring of Filipina nurses is not a new practice in US hospitals, very few studies have detailed how these nurses have adjusted to US nursing practices. This study examines how Filipina nurses transition into their role as nurses and adapt to nursing practice in the US. Following a qualitative approach, 31 Filipina nurses were interviewed as participants. The data were audio-taped and transcribed verbatim, using the method of constant comparison. Analysis revealed that transitioning from Philippine to US nursing practice formed the basis of the social adaptation process, which occurred in three stages: pre-arrival, early adaptation, and late adaptation. Participant-recommended strategies to address adaptation needs experienced at each of these stages are shared. All participants experienced challenges while adjusting to the US healthcare system and cultural landscape.